Thot L-Leucine STRENGTH & MUSCLES – Specific Functions

L-Leucine support muscle growth. How?

L-Leucine improve muscle metabolism. How?

Aids muscle recovery after exercise. How?

L-leucine attenuates the decline in power output following exercise at high altitude. How?

L-leucine increases protein synthesis. How?

L- leucine increase recovery and protein synthesis in skeletal muscle during recovery from sustained strength exercise How?

L-Leucine improves mental performance after exercise. How?

L-leucine promotes muscle recovery after exercise through several mechanisms, including:

L-leucine Help maintain a healthy immune system

L-leucine improve hormonal balance of the body. How?

L-Leucine improve Longevity. How?

L-Leucine cannot be produced by the body and must be obtained through diet or supplementation.

Read the master article  to learn the details about how L-Leucine do all this 11 claims:

L-Leucine; the best key to muscle recovery, health & longevity in 2023

1       What is L-Leucine and how it improves our body?

1.1      L-leucine is an essential amino acid, which means that it cannot be produced by the body and must be obtained through the diet. It is found in a variety of foods, including meat, fish, beans, and nuts.

• It is recommended to combine L-leucine with the rest of Essential Amino Acids that the body does not produce: L-valine, L-isoleucine, L-tryptophan, L-phenylalanine, L-methionine, L-lysine, L-threonine, L-histidine.
• The recommended way to administer L-leucine in combination with other essential amino acids (EAAs) depends on the specific goal or purpose of supplementation.
• For muscle protein synthesis and recovery, it is recommended to consume a combination of EAAs, including L-leucine, in a dose range of 10-15 grams per day. The optimal ratio of EAAs varies, but a common ratio is 2:1:1 of leucine, isoleucine, and valine. This ratio is based on the idea that leucine is the most potent stimulator of muscle protein synthesis, and the other two amino acids support the process.
• For endurance performance, a combination of EAAs with carbohydrates may be more beneficial. This is because the combination can help reduce muscle damage, preserve glycogen stores, and delay fatigue during prolonged exercise.
• For weight loss, a combination of EAAs may help preserve muscle mass while in a caloric deficit. This can be particularly important for individuals on a low-calorie diet, as they may be at risk of losing muscle mass along with body fat.
• In general, it is best to consume EAAs in a balanced and varied diet, as they work together to support many important functions in the body. However, for individuals who may not be able to consume enough EAAs through diet alone, supplementation may be beneficial. It is important to consult with a healthcare provider before starting any supplementation regimen.

1.2      Body Functions for L-Leucine

L-leucine has several important functions in the body. It is a building block for protein synthesis, and it also plays a role in energy production and muscle metabolism. Some of the potential benefits of L-leucine include:

• Muscle building: L-leucine is one of the three branched-chain amino acids (BCAAs) and has been shown to stimulate muscle protein synthesis, which can help increase muscle mass and strength.
• Athletic performance: L-leucine may improve endurance and exercise performance by reducing muscle damage and fatigue during prolonged exercise.
• Blood sugar control: L-leucine may help regulate blood sugar levels by promoting glucose uptake in cells and increasing insulin sensitivity.
• Wound healing: L-leucine may aid in the healing of wounds by stimulating the production of new tissue.
• Cognitive function: L-leucine has been found to have potential cognitive benefits, such as improving memory and reducing cognitive decline in aging adults.

1.3      L-Leucine in health and nutrition

• Leucine, like Valine and Isoleucine, is a BCAA. It is one of the two exclusive ketogenic amino acids, Lysine being the other one[1].
• Leucine stimulates muscle protein synthesis, being directly involved in the functions of anabolism or body growth and development[2]. It seems to be one of the most abundant essential amino acids in high quality protein foods.
• Leucine helps in protein synthesis through activation of the mammalian target of rapamycin (mTOR) signaling pathway. It promotes energy metabolism (glucose uptake, mitochondrial biogenesis, and fatty acid oxidation) to provide energy for protein synthesis and inhibits protein degradation. Approximately 80 % of Leucine is normally used for protein synthesis, while the rest is converted to its metabolites (α-KIC and HMB) in skeletal muscle, which are also believed to increase protein synthesis, inhibit protein degradation, and regulate energy[3].
• Regarding weight management, it is well known that when energy intake exceeds energy expenditure, the surplus energy is stored as fat in the adipose tissue. Data suggests that L-Leucine influences energy balance, regulating the physiological processes involved in obesity[4].
• Studies done on mice show that L-Leucine supplementation seems to influence glucose homeostasis in diet-induced obesity improving metabolic markers if it is offered during the development of the metabolic disorder[5].
• Moreover, L-Leucine has been suggested as an effective pharmaconutrient in preventing and treating sarcopenia and type 2 diabetes. Recent in vivo studies in humans show that free L-Leucine could improve muscle protein synthesis in the elderly[6].
• To summarize its main benefits, L-Leucine influences many cell functions including activation of enzymes, enabling ATP generation, insulin secretion and activation of signaling pathways. It stimulates anabolic hormone secretion and directly signals protein deposition and growth through protein synthesis stimulation and proteolysis restriction. In animals, dietary L-Leucine has reversed adverse influences of a high fat diet. In humans, it showed a healthy weight maintenance, with evidence accumulating to sustain this[7].
• L-Leucine also has an ability to attenuate oxidative stress[8], therefore being an effective antioxidant.
• In addition, L-Leucine may have a role in regulating T cell activation[9], therefore regulating the immune response. It also may have a protective effect in epileptic seizures[10].
• To add to its potential, it has been found that L-Leucine could dramatically boost axonal outgrowth and regeneration[11], being a very good candidate for nervous system recovery.
• A high human Leucine requirement may be explained due to a high demand in metabolic adaptation requirements.

 

1.4 According to EFSA (European Food Safety Administration), L-Leucine have gained some important health claims. The most important ones are as follows:

1. L-Leucine support muscle growth
2. L-Leucine improve muscle metabolism
3. L-Leucine Aids muscle recovery after exercise
4. L-leucine attenuates the decline in power output following exercise at high altitude
5. L-leucine increases protein synthesis
6. L- leucine increase recovery and protein synthesis in skeletal muscle during recovery from sustained strength exercise
7. L-Leucine improves mental performance after exercise
8. L-leucine promotes muscle recovery after exercise
9. L-leucine Help maintain a healthy immune system
10. L-leucine improve hormonal balance of the body
11. L-Leucine improve longevity

[1] https://books.google.ro/books?id=sSyMAwAAQBAJ&pg=PA266&redir_esc=y#v=onepage&q&f=false

[2] https://pubchem.ncbi.nlm.nih.gov/compound/L-leucine

[3] Yehui Duan 1 2 , Fengna Li 3 , Yinghui Li 1 2 , Yulong Tang 1 , Xiangfeng Kong 1 , Zemeng Feng 1 , Tracy G Anthony 4 , Malcolm Watford 4 , Yongqing Hou 5 , Guoyao Wu 5 6 , Yulong Yin 7 8 9 – “The role of leucine and its metabolites in protein and energy metabolism”.Amino Acids . 2016 Jan;48(1):41-51. doi: 10.1007/s00726-015-2067-1. Epub 2015 Aug 9.

[4] Liam McAllan 1 , Paul D Cotter, Helen M Roche, Riitta Korpela, Kanishka N Nilaweera – “Impact of leucine on energy balance”.J Physiol Biochem . 2013 Mar;69(1):155-63. doi: 10.1007/s13105-012-0170-2. Epub 2012 Apr 26.

[5] Henver S Brunetta 1 2 , Carolina Q de Camargo 1 3 , Everson A Nunes 4 5 6 – “Does L-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance?” A systematic review.Amino Acids . 2018 Dec;50(12):1663-1678. doi: 10.1007/s00726-018-2658-8. Epub 2018 Sep 27.

[6] Marika Leenders 1 , Luc J C van Loon – “Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes” – Nutr Rev . 2011 Nov;69(11):675-89. doi: 10.1111/j.1753-4887.2011.00443.x.

[7] D Joe Millward 1 – “Knowledge gained from studies of leucine consumption in animals and humans” – J Nutr . 2012 Dec;142(12):2212S-2219S. doi: 10.3945/jn.111.157370. Epub 2012 Oct 17.

[8] Ochuko L Erukainure 1 , Olubunmi Atolani 2 , Priyanka Banerjee 3 , Renata Abel 3 4 , Ofentse J Pooe 5 , Oluyomi S Adeyemi 6 , Robert Preissner 3 , Chika I Chukwuma 7 , Neil A Koorbanally 8 , Md Shahidul Islam 5 – “Oxidative testicular injury: effect of L-leucine on redox, cholinergic and purinergic dysfunctions, and dysregulated metabolic pathways” – Amino Acids . 2021 Mar;53(3):359-380. doi: 10.1007/s00726-021-02954-4. Epub 2021 Feb 14.

[9] Advances în Nutrition – AN INTERNATIONAL REVIEW JOURNAL – A journal of the American Society for Nutrition – June 2025, Volume 16, Issue 6

[10] Adam L Hartman a,b,1, Polan Santos a, Kenneth J O’Riordan c, Carl E Stafstrom a,c, J Marie Hardwick a,b,1 – “Potent anti-seizure effects of D-leucine”.Neurobiol Dis. Author manuscript; available in PMC: 2016 Oct 1. Published in final edited form as: Neurobiol Dis. 2015 Jun 6;82:46–53. doi: 10.1016/j.nbd.2015.05.013

[11] Chao Ma # 1 , Long Teng # 1 , Ge Lin 1 , Beibei Guo 1 , Run Zhuo 1 , Xiaowei Qian 1 , Tuchen Guan 1 , Ronghua Wu 1 , Yan Liu 1 , Mei Liu 1 – “L-leucine promotes axonal outgrowth and regeneration via mTOR activation.” – FASEB J . 2021 May;35(5):e21526. doi: 10.1096/fj.202001798RR.

2. Suggested Usage:

A dose of 2-5 grams of L-Leucine per day is commonly used to promote muscle growth and recovery.

Doses may be adjusted as needed according to the following recommendations:

2. 1.Recommendation and posology

 

L-Leucine posology According to EFSA (European Food Safety Administration),

Reference body weights of population groups in Europe (SCF, 1993)
Age (years)	Male Mean weight (kg)	Female Mean weight (kg)
1-3	13	12.5
4-6	20	19
7-10	28.5	29
11-14	44.5	45
15-17	61.5	53.5
18-29	74.6	62.1
30-59	74.6	62.1
60-74	73.5	66.1
≥75	73.5	66.1

 

• The recommended daily intake of L-leucine can vary depending on a person’s age, sex, weight, and activity level. The Dietary Reference Intake (DRI) for L-leucine has not been established separately, as it is part of the group of essential amino acids. However, the daily recommended intake of protein for adults is generally 0.8 grams per kilogram of body weight. For example, a person weighing 68 kg (150 lbs) would need about 55 grams of protein per day.

 

• L-leucine supplements are available in various forms, including powders, capsules, and tablets. The dosage and form of L-leucine supplementation can vary depending on the individual’s needs and goals. In general, a dosage of 2-5 grams of L-leucine per day is commonly used to promote muscle growth and recovery.

 

• It is important to note that L-leucine supplements should not be used as a substitute for a healthy diet. It is best to consume L-leucine as part of a well-balanced diet that includes a variety of protein-rich foods, such as meat, poultry, fish, eggs, dairy, legumes, and nuts. It is also recommended to speak with a healthcare provider or registered dietitian before starting any new supplements or making significant dietary changes.

3. Why Thot L-Leucine is so special?:

• THOT L-LEUCINE has a very low molecular size. Its small size allows it to

penetrate places where other amino acids cannot, even crossing the blood-brain

barrier (brain) or the pericardium (heart). Being a muscle, the heart needs

L-Leucine to reach it

 

• In addition, THOT L-LEUCINE has a high density, with more molecules per dose

than all products currently available on the market

 

• The food supplement THOT L-LEUCINE is orthomolecular. This means that it is

properly folded to the left so that the body can use it instantly, without the need

for any other pre-use process other than dissolution

• So far, the best L-Leucine suppliers on the market have been able to deliver

whey based products. Whey has stood the test of time, but modern technology

brings us to the next level. Current supplements manage to raise muscle protein

synthesis up to 20-30%. But what if you found out that you could increase this

percentage of effectiveness to almost 80% with THOT L-LEUCINE?

 

• THOT L-LEUCINE is 100% plant-based. Sources of protein in nature are either

plants or animals/animal products. Animals are intermediate organisms in the life

chain, built to extract the essential amino acids from plants, thus bringing them

into a single organism. Thot Nutrition understands the natural order of life and

uses modern technology to produce and extract all 9 essential amino acids

through biosynthesis, directly from plants, avoiding all the harmful effects of meat

consumption. This actually means that you can have the amino acids in a pill

without having to take other supplements

 

• THOT L-LEUCINE does not contain sugar or other artificial sweeteners, gluten,

dairy products, fats, corn, wheat or grains or GMOs (Genetically Modified

Organisms)

• BEST suited for Fasting and Keto diets (Ketogenic Nutrition – The fundamentals of Keto diet – 100% Powerful Ketogenic) since it does not increase the blood sugar spike. (It feeds your body directly with optimal amino acids)